Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
[HTML][HTML] Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer
The tumor microenvironment consists of diverse, complex etiological factors. The matrix
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …
Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of …
E Hong, W Barczak, S Park, JS Heo, A Ooshima… - Cell Death & …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal type of cancer and the third
leading cause of cancer death with the lowest 5-year survival rate. Heterogeneity, difficulty in …
leading cause of cancer death with the lowest 5-year survival rate. Heterogeneity, difficulty in …
Integration of pan-cancer single-cell and spatial transcriptomics reveals stromal cell features and therapeutic targets in tumor microenvironment
Y Du, J Shi, J Wang, Z Xun, Z Yu, H Sun, R Bao… - Cancer Research, 2024 - AACR
Stromal cells are physiologically essential components of the tumor microenvironment
(TME) that mediates tumor development and therapeutic resistance. Development of a …
(TME) that mediates tumor development and therapeutic resistance. Development of a …
[HTML][HTML] Vactosertib, TGF-β receptor I inhibitor, augments the sensitization of the anti-cancer activity of gemcitabine in pancreatic cancer
JE Lee, P Lee, YC Yoon, BS Han, S Ko, MS Park… - Biomedicine & …, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) exhibits a pronounced extracellular matrix
(ECM)-rich response, which is produced by an excessive amount of transforming growth …
(ECM)-rich response, which is produced by an excessive amount of transforming growth …
An Optimized Method for LC–MS-Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic Cancer
Accurate and reliable quantification of organic acids with carboxylic acid functional groups in
complex biological samples remains a major analytical challenge in clinical chemistry …
complex biological samples remains a major analytical challenge in clinical chemistry …
Integrative proteomics and n-glycoproteomics reveal the synergistic anti-tumor effects of aspirin-and gemcitabine-based chemotherapy on pancreatic cancer cells
X Li, R Kong, W Hou, J Cao, L Zhang, X Qian, L Zhao… - Cellular Oncology, 2024 - Springer
Objective and design Pancreatic cancer is a highly malignant tumor that is well known for its
poor prognosis. Based on glycosylation, we performed integrated quantitative N …
poor prognosis. Based on glycosylation, we performed integrated quantitative N …
A pancreatic adenocarcinoma mimicking hepatoid carcinoma of uncertain histogenesis: A case report and literature review
In rare cases, metastatic adenocarcinomas of different origin may exhibit the features of
hepatoid carcinoma (HC), a rare malignant epithelial tumor, most commonly occurring in the …
hepatoid carcinoma (HC), a rare malignant epithelial tumor, most commonly occurring in the …
Targeting Tumor Microenvironment Akt Signaling Represents a Potential Therapeutic Strategy for Aggressive Thyroid Cancer
S Mirshahidi, IJ Yuan, A Simental, SC Lee… - International Journal of …, 2023 - mdpi.com
Effects of the tumor microenvironment (TME) stromal cells on progression in thyroid cancer
are largely unexplored. Elucidating the effects and underlying mechanisms may facilitate the …
are largely unexplored. Elucidating the effects and underlying mechanisms may facilitate the …
Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach
S Gurzu, I Jung - Gastrointestinal Cancers: An Interdisciplinary Approach, 2022 - Springer
Abstract Since 1968, when Betty Hay first described the concept of epithelial-mesenchymal
transition (EMT), over 54,000 articles have been published on this topic in the Medline and …
transition (EMT), over 54,000 articles have been published on this topic in the Medline and …