Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

The role of inflammation and genetics in periodontal disease

BG Loos, TE Van Dyke - Periodontology 2000, 2020 - Wiley Online Library
Periodontitis is a complex disease:(a) various causative factors play a role simultaneously
and interact with each other; and (b) the disease is episodic in nature, and bursts of disease …

Global burden of oral diseases: emerging concepts, management and interplay with systemic health

LJ Jin, IB Lamster, JS Greenspan, NB Pitts… - Oral …, 2016 - Wiley Online Library
Objectives This study presents the global burden of major oral diseases with an exegetical
commentary on their current profiles, the critical issues in oral healthcare and future …

Long noncoding RNAs in cardiovascular diseases

S Uchida, S Dimmeler - Circulation research, 2015 - Am Heart Assoc
In recent year, increasing evidence suggests that noncoding RNAs play important roles in
the regulation of tissue homeostasis and pathophysiological conditions. Besides small …

Long noncoding RNAs: from clinical genetics to therapeutic targets?

RA Boon, N Jaé, L Holdt, S Dimmeler - Journal of the American College of …, 2016 - jacc.org
Recent studies suggest that the majority of the human genome is transcribed, but only about
2% accounts for protein-coding exons. Long noncoding RNAs (lncRNAs) constitute a …

Long noncoding RNAs in patients with acute myocardial infarction

M Vausort, DR Wagner, Y Devaux - Circulation research, 2014 - Am Heart Assoc
Rationale: Long noncoding RNAs (lncRNAs) constitute a novel class of noncoding RNAs
that regulate gene expression. Although recent data suggest that lncRNAs may be …

A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks

O Parnas, M Jovanovic, TM Eisenhaure, RH Herbst… - Cell, 2015 - cell.com
Finding the components of cellular circuits and determining their functions systematically
remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled …

Classification and diagnosis of aggressive periodontitis

DH Fine, AG Patil, BG Loos - Journal of clinical periodontology, 2018 - Wiley Online Library
Objective Since the initial description of aggressive periodontitis (AgP) in the early 1900s,
classification of this disease has been in flux. The goal of this manuscript is to review the …

Long noncoding RNAs in cardiac development and ageing

Nature Reviews Cardiology, 2015 - nature.com
A large part of the mammalian genome is transcribed into noncoding RNAs. Long
noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene …

[HTML][HTML] Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a

E Zhang, R Kong, D Yin, L You, M Sun, L Han, T Xu… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Long noncoding RNAs are involved in diseases including cancer. Here, we reported that
ANRIL (CDKN2B-AS1), a 3.8-kb long noncoding RNA, recruiting and binding to PRC2, was …