Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Sleep disturbances including insomnia independently contribute to risk of inflammatory
disorders and major depressive disorder. This review and overview provides an integrated …

Sleep has a critical role in promoting health. Research over the past decade has
documented that sleep disturbance has a powerful influence on the risk of infectious …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Observational studies of necrotic core progression identify intraplaque hemorrhage as a
critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of …

Background Inflammation is associated with increased risk of cardiovascular disorders,
arthritis, diabetes mellitus, and mortality. The effects of sleep loss on the cellular and …

Raised serum levels of interferon (IFN)-α have been observed in systemic lupus
erythematosus (SLE) patients, and these levels are correlated with both disease activity and …

Alzheimer's disease (AD) is the most common type of dementia and a neurodegenerative
disorder characterized by memory deficits especially forgetting recent information, recall …

Background Sleep disturbance is associated with activation of systemic and cellular
inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes …

The toll-like receptors (TLRs) are a class of transmembrane-spanning receptors that are
sentinels of both innate and adaptive immunity. Statins (3-hydroxy-3-methylglutaryl …