The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Inactivation of the β 4 subunit of the calcium channel in the mouse neurological mutant
lethargic results in a complex neurological disorder that includes absence epilepsy and …

Sydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

The auxiliary β subunit is essential for functional expression of high voltage-activated Ca 2+
channels. This effect is partly mediated by a facilitation of the intracellular trafficking of α 1 …

Calcium channel β subunits have marked effects on the trafficking and on several of the
biophysical properties of all high voltage activated calcium channels. In this article I shall …

Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown
pathogenesis. Given their prominent role in brain function and disease, we hypothesized …

Voltage-activated calcium channels regulate the intracellular calcium concentration and
contribute thereby to calcium signalling in numerous cell types. These channels are widely …

Rationale: Ca2+-induced Ca2+ release (CICR) in normal hearts requires close
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …