Emerging roles of tRNA-derived fragments in cancer

M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

[HTML][HTML] tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus …

X Yu, Y Xie, S Zhang, X Song, B Xiao, Z Yan - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract tRNA-derived fragments (tRFs) are a new category of regulatory noncoding RNAs
with distinct biological functions in cancers and stress-induced diseases. Herein, we first …

Deciphering the tRNA-derived small RNAs: origin, development, and future

B Liu, J Cao, X Wang, C Guo, Y Liu, T Wang - Cell Death & Disease, 2021 - nature.com
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …

A tRNA fragment, 5′-tiRNAVal, suppresses the Wnt/β-catenin signaling pathway by targeting FZD3 in breast cancer

D Mo, P Jiang, Y Yang, X Mao, X Tan, X Tang, D Wei… - Cancer letters, 2019 - Elsevier
Abstract tRNA-derived fragments offer a recently identified group of non-coding single-
stranded RNAs that are often as abundant as microRNAs in cancer cells and play important …

Angiogenin and copper crossing in wound healing

LM Cucci, C Satriano, T Marzo… - International Journal of …, 2021 - mdpi.com
Angiogenesis plays a key role in the wound healing process, involving the migration,
growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance …

tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer

D Mo, F He, J Zheng, H Chen, L Tang, F Yan - Frontiers in oncology, 2021 - frontiersin.org
tRNA derivatives have been identified as a new kind of potential biomarker for cancer.
Previous studies have identified that there were 30 differentially expressed tRNAs …

Neuron‐specific translational control shift ensures proteostatic resilience during ER stress

K Wolzak, A Nölle, M Farina, TEM Abbink… - The EMBO …, 2022 - embopress.org
Proteostasis is essential for cellular survival and particularly important for highly specialised
post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase …

RTCB complex regulates stress-induced tRNA cleavage

Y Akiyama, Y Takenaka, T Kasahara, T Abe… - International Journal of …, 2022 - mdpi.com
Under stress conditions, transfer RNAs (tRNAs) are cleaved by stress-responsive RNases
such as angiogenin, generating tRNA-derived RNAs called tiRNAs. As tiRNAs contribute to …

[HTML][HTML] Transfer RNA-derived small RNAs: potential applications as novel biomarkers for disease diagnosis and prognosis

Y Jia, W Tan, Y Zhou - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
Transfer RNA-derived small RNA (tsRNA) s are novel non-coding RNAs, expressed in a
variety of tissues and organs. Two subtypes of tsRNAs have been reported: tRNA-derived …

C/D box snoRNA SNORD113-6 guides 2′-O-methylation and protects against site-specific fragmentation of tRNALeu (TAA) in vascular remodeling

E van Ingen, PAM Engbers, T Woudenberg… - … Therapy-Nucleic Acids, 2022 - cell.com
C/D box small nucleolar RNAs (snoRNAs) of the DLK1-DIO3 locus are associated with
vascular remodeling and cardiovascular disease. None of these snoRNAs has any known …