Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

TGF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a
condition characterized by alveolar edema. A unique TGF-β pathway is described, which …

Using gene expression data to enhance our knowledge of control networks relevant to
cancer biology and therapy is a challenging but urgent task. Based on the premise that …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

Mammalian airways are protected from infection by a thin film of airway surface liquid (ASL)
which covers airway epithelial surfaces and acts as a lubricant to keep mucus from adhering …

Anionic phospholipids are critical constituents of the inner leaflet of the plasma membrane,
ensuring appropriate membrane topology of transmembrane proteins. Additionally, in …

The mechanisms of regulation of ENaC are increasingly understood to be a complex
interplay of many different levels and systems. Proteolytic cleavage of α and γ subunits plays …

Phosphoinositides are membrane-delimited regulators of protein function and control many
different cellular targets. The differentially phosphorylated isoforms have distinct …

The epsins are a conserved family of endocytic adaptors essential for cell viability in yeast
and for embryo development in higher eukaryotes. Epsins function as adaptors by …