The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-
CMs) have great potential as a cell source for therapeutic applications such as regenerative …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Targeted therapeutics, particularly those that inhibit the activity of protein kinases that are
mutated and/or overexpressed in cancer, have revolutionized the treatment of some cancers …

Aims/hypothesis Previous studies have shown that alterations in vascular, metabolic,
inflammatory and haemocoagulative functions characterise the metabolic syndrome …

Improved methodologies for modeling cardiac disease phenotypes and accurately
screening the efficacy and toxicity of potential therapeutic compounds are actively being …

Leukemia inhibitory factor (LIF) is a polyfunctional glycoprotein cytokine whose inducible
production can occur in many, perhaps all, tissues. LIF acts on responding cells by binding …

There is a growing body of evidence that G protein-coupled receptors function in the context
of plasma membrane signaling compartments. These compartments may facilitate …

Alterations in intracellular Ca2+ homeostasis are an important trigger of pathological cardiac
remodeling; however, mechanisms governing context-dependent changes in Ca2+ influx …