The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …

Atherosclerosis is the most common form of vascular disease and constitutes the major
cause of death, with 17.5 million related deaths annually (31% of global mortality). 1 …

Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

Using 2.1-µm high-resolution microcomputed tomography, we have examined the spatial
distribution, clustering, and shape of nearly 35,000 microcalcifications (µCalcs)≥ 5 µm in …

Macrophage apoptosis is an important feature of atherosclerotic plaque development.
Research directed at understanding the functional consequences of macrophage death in …

The clinical complications of atherosclerosis are caused by thrombus formation, which in
turn results from rupture of an unstable atherosclerotic plaque. The formation of …

Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite
current therapeutic developments, there is an unmet necessity in the prevention of …

The leading cause of major morbidity and mortality in most countries around the world is
atherosclerotic cardiovascular disease, most commonly caused by thrombotic occlusion of a …

The role of microcalcifications (μCalcs) in the biomechanics of vulnerable plaque rupture is
examined. Our laboratory previously proposed (Ref.), using a very limited tissue sample, that …

Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age
and tissue damage and secrete factors that promote atherosclerotic plaque vulnerability and …