Ten things you should know about transposable elements
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …
extent of their impact on genome evolution, function, and disease remain a matter of intense …
Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
Cryptic and abundant marine viruses at the evolutionary origins of Earth's RNA virome
Whereas DNA viruses are known to be abundant, diverse, and commonly key ecosystem
players, RNA viruses are insufficiently studied outside disease settings. In this study, we …
players, RNA viruses are insufficiently studied outside disease settings. In this study, we …
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
PD-1 blockade has transformed the management of advanced clear cell renal cell
carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely …
carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely …
RepeatModeler2 for automated genomic discovery of transposable element families
The accelerating pace of genome sequencing throughout the tree of life is driving the need
for improved unsupervised annotation of genome components such as transposable …
for improved unsupervised annotation of genome components such as transposable …
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …
Alternative tumour-specific antigens
The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has
accelerated within the past decade. The most commonly studied class of TSAs are those …
accelerated within the past decade. The most commonly studied class of TSAs are those …
[HTML][HTML] Resurrection of endogenous retroviruses during aging reinforces senescence
Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
Human endogenous retroviruses are ancient acquired elements still shaping innate immune responses
N Grandi, E Tramontano - Frontiers in immunology, 2018 - frontiersin.org
About 8% of our genome is composed of sequences with viral origin, namely human
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …
Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma
CC Smith, KE Beckermann, DS Bortone… - The Journal of …, 2019 - Am Soc Clin Investig
Human endogenous retroviruses (hERVs) are remnants of exogenous retroviruses that have
integrated into the genome throughout evolution. We developed a computational workflow …
integrated into the genome throughout evolution. We developed a computational workflow …