Genetic and biological drivers of prostate cancer disparities in Black men
J Gong, DM Kim, MR Freeman, H Kim, L Ellis… - Nature Reviews …, 2024 - nature.com
Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …
Overcoming cancer drug-resistance calls for novel strategies targeting abnormal alternative splicing
J Zhang, X Xu, H Deng, L Liu, Y Xiang… - Pharmacology & …, 2024 - Elsevier
Abnormal gene alternative splicing (AS) events are strongly associated with cancer
progression. Here, we summarize AS events that contribute to the development of drug …
progression. Here, we summarize AS events that contribute to the development of drug …
Aberrant PI3Kδ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
Introduction PI3K/AKT signaling pathway is upregulated in a broad spectrum of cancers.
Among the class I PI3Ks (PI3Kδ/β/δ isoforms), PI3Kδ has been implicated in hematologic …
Among the class I PI3Ks (PI3Kδ/β/δ isoforms), PI3Kδ has been implicated in hematologic …
Combination of miR-99b-5p and Enzalutamide or Abiraterone Synergizes the Suppression of EMT-Mediated Metastasis in Prostate Cancer
Simple Summary To date, effective treatment for metastatic prostate cancer (PCa) remains a
clinical challenge. Our previous study demonstrated that tumor suppressive miR-99b-5p …
clinical challenge. Our previous study demonstrated that tumor suppressive miR-99b-5p …