[HTML][HTML] Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis

T Iba, JH Levy - Journal of Thrombosis and Haemostasis, 2018 - Elsevier
The inflammatory response and the activation of coagulation are two important responses in
a host's defense against infection. These mechanisms do not work independently, but …

[PDF][PDF] A comprehensive review on eryptosis

E Pretorius, JN du Plooy, J Bester - Cellular Physiology and …, 2016 - karger.com
Erythrocytes (RBCs) are extremely sensitive cells, and although they do not have nuclei and
mitochondria, are important health indicators. This is particularly true because, during …

The effect of sepsis on the erythrocyte

RM Bateman, MD Sharpe, M Singer… - International journal of …, 2017 - mdpi.com
Sepsis induces a wide range of effects on the red blood cell (RBC). Some of the effects
including altered metabolism and decreased 2, 3-bisphosphoglycerate are preventable with …

Eryptosis: programmed death of nucleus-free, iron-filled blood cells

P Dreischer, M Duszenko, J Stein, T Wieder - Cells, 2022 - mdpi.com
Human erythrocytes are organelle-free cells packaged with iron-containing hemoglobin,
specializing in the transport of oxygen. With a total number of approximately 25 trillion cells …

Metabolic influences modulating erythrocyte deformability and eryptosis

JF Brun, E Varlet-Marie, J Myzia… - Metabolites, 2021 - mdpi.com
Many factors in the surrounding environment have been reported to influence erythrocyte
deformability. It is likely that some influences represent reversible changes in erythrocyte …

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

DB Kell, E Pretorius - Biological Reviews, 2018 - Wiley Online Library
Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …

Haptoglobin therapeutics and compartmentalization of cell-free hemoglobin toxicity

PW Buehler, DJ Schaer - Trends in molecular medicine, 2020 - cell.com
Hemolysis and accumulation of cell-free hemoglobin (Hb) in the circulation or in confined
tissue compartments such as the subarachnoid space is an important driver of disease …

A dormant microbial component in the development of preeclampsia

DB Kell, LC Kenny - Frontiers in medicine, 2016 - frontiersin.org
Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of
morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE …

Role of extracellular vesicles in the development of sepsis-induced coagulopathy

T Iba, H Ogura - Journal of Intensive Care, 2018 - Springer
Background The advances of research on extracellular vesicles (EVs) are of particular
interest to the clinicians as well as the researchers who are studying coagulation disorder in …

Apoptosis and eryptosis: similarities and differences

A Tkachenko - Apoptosis, 2024 - Springer
Eryptosis is a regulated cell death (RCD) of mature erythrocytes initially described as a
counterpart of apoptosis for enucleated cells. However, over the recent years, a growing …