The pathogenic mechanisms underlying vascular cognitive impairment and dementia
(VCID) remain controversial due to the heterogeneity of vascular causes and complexity of …

The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …

Aims We induced the AD-like rat models injected by AlCl 3 and D-galactose, to explore the
effects of an oral treatment of A. muciniphila on AD-like rats with periodontitis and its …

Growing evidence suggest that there is a connection between Parkinson's disease (PD) and
insulin dysregulation in the brain, whilst the connection between PD and type 2 diabetes …

Background Diabetes mellitus (DM) and chronic cerebral hypoperfusion (CCH) are both risk
factors for cognitive impairment. However, whether DM and CCH can synergistically …

Objective To explore whether Fusobacterium nucleatum could lead to behavioral and
pathological changes in Alzheimer's disease (AD)-like model rat and whether they could …

Vascular dementia (VaD) is the second most common type of dementia worldwide. Although
there are five FDA-approved drugs for the treatment of Alzheimer's disease (AD), none of …

Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which
main clinical manifestations are cognitive dysfunction, memory impairment and mental …

Alzheimer's disease (AD) is a significant form of dementia. Embelin (EMB) is a natural
compound with varied actions that could help prevent AD pathology. Herein, we have …

Vascular dementia (VaD) is a progressive cognitive impairment caused by a reduced blood
supply to the brain. Chronic cerebral hypoperfusion (CCH) is one cause of VaD; it induces …