GB Collin, N Gogna, B Chang, N Damkham, J Pinkney… - Cells, 2020 - mdpi.com
Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …
Y Li, J Liang, B Deng, Y Jiang, J Zhu, L Chen… - Current Issues in …, 2023 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 system (Cas9) has been used at length to optimize multiple aspects of germplasm …
DL Bordin, L Lirussi, H Nilsen - DNA repair, 2021 - Elsevier
The integrity of the genetic information is continuously challenged by numerous genotoxic insults, most frequently in the form of oxidation, alkylation or deamination of the bases that …
M Liu, N Zhong, L Zhang, Q Zhang, X Tian, F Ma… - Talanta, 2024 - Elsevier
Human alkyladenine DNA glycosylase (hAAG) is essential for repairing alkylated and deaminated bases, and it has become a prospective diagnosis biomarker and a therapeutic …
Probing the sequence alterations, structures, interactions, and other important aspects of nucleic acids serves as the cornerstone of understanding nucleic acid-mediated biology and …
A Bacolla, S Sengupta, Z Ye, C Yang… - Nucleic acids …, 2021 - academic.oup.com
Human genome stability requires efficient repair of oxidized bases, which is initiated via damage recognition and excision by NEIL1 and other base excision repair (BER) pathway …
Y Peng, H Pei - Journal of Zhejiang University-SCIENCE B, 2021 - Springer
Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous metabolites, represent a major form of DNA damage in cells. The repair of alkylation …
KM Miner, AS Jamenis, TN Bhatia, RN Clark… - Progress in …, 2022 - Elsevier
Lewy body disorders are characterized by oxidative damage to DNA and inclusions rich in aggregated forms of α-synuclein. Among other roles, apurinic/apyrimidinic endonuclease 1 …
M Duan, S Sivapragasam, JS Antony, J Ulibarri… - Elife, 2022 - elifesciences.org
DNA base damage arises frequently in living cells and needs to be removed by base excision repair (BER) to prevent mutagenesis and genome instability. Both the formation …