Genotoxic therapy and resistance mechanism in gliomas

F Lang, Y Liu, FJ Chou, C Yang - Pharmacology & therapeutics, 2021 - Elsevier
Glioma is one of the most common and lethal brain tumors. Surgical resection followed by
radiotherapy plus chemotherapy is the current standard of care for patients with glioma. The …

Mouse models of inherited retinal degeneration with photoreceptor cell loss

GB Collin, N Gogna, B Chang, N Damkham, J Pinkney… - Cells, 2020 - mdpi.com
Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

Applications and prospects of CRISPR/Cas9-mediated base editing in plant breeding

Y Li, J Liang, B Deng, Y Jiang, J Zhu, L Chen… - Current Issues in …, 2023 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 system (Cas9) has been used at length to optimize multiple aspects of germplasm …

[HTML][HTML] Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation

DL Bordin, L Lirussi, H Nilsen - DNA repair, 2021 - Elsevier
The integrity of the genetic information is continuously challenged by numerous genotoxic
insults, most frequently in the form of oxidation, alkylation or deamination of the bases that …

Single probe-based catalytic quantum dot FRET nanosensor for human alkyladenine DNA glycosylase detection

M Liu, N Zhong, L Zhang, Q Zhang, X Tian, F Ma… - Talanta, 2024 - Elsevier
Human alkyladenine DNA glycosylase (hAAG) is essential for repairing alkylated and
deaminated bases, and it has become a prospective diagnosis biomarker and a therapeutic …

Multifaceted nucleic acid probing with a rationally upgraded molecular rotor

TK Kha, Q Shi, N Pandya, RY Zhu - Chemical Science, 2024 - pubs.rsc.org
Probing the sequence alterations, structures, interactions, and other important aspects of
nucleic acids serves as the cornerstone of understanding nucleic acid-mediated biology and …

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin

A Bacolla, S Sengupta, Z Ye, C Yang… - Nucleic acids …, 2021 - academic.oup.com
Human genome stability requires efficient repair of oxidized bases, which is initiated via
damage recognition and excision by NEIL1 and other base excision repair (BER) pathway …

DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy

Y Peng, H Pei - Journal of Zhejiang University-SCIENCE B, 2021 - Springer
Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous
metabolites, represent a major form of DNA damage in cells. The repair of alkylation …

α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans

KM Miner, AS Jamenis, TN Bhatia, RN Clark… - Progress in …, 2022 - Elsevier
Lewy body disorders are characterized by oxidative damage to DNA and inclusions rich in
aggregated forms of α-synuclein. Among other roles, apurinic/apyrimidinic endonuclease 1 …

High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors

M Duan, S Sivapragasam, JS Antony, J Ulibarri… - Elife, 2022 - elifesciences.org
DNA base damage arises frequently in living cells and needs to be removed by base
excision repair (BER) to prevent mutagenesis and genome instability. Both the formation …