Thirty years of HER3: from basic biology to therapeutic interventions
HM Haikala, PA Jänne - Clinical Cancer Research, 2021 - AACR
HER3 is a pseudokinase member of the EGFR family having a role in both tumor
progression and drug resistance. Although HER3 was discovered more than 30 years ago …
progression and drug resistance. Although HER3 was discovered more than 30 years ago …
Prospects for pharmacological targeting of pseudokinases
Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling
Protein kinases are present in all domains of life and play diverse roles in cellular signaling.
Whereas the impact of substrate phosphorylation by protein kinases has long been …
Whereas the impact of substrate phosphorylation by protein kinases has long been …
[HTML][HTML] Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels
As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …
Effects of HER family–targeting tyrosine kinase inhibitors on antibody-dependent cell-mediated cytotoxicity in HER2-expressing breast cancer
DM Collins, SF Madden, N Gaynor, D AlSultan… - Clinical Cancer …, 2021 - AACR
Purpose: Antibody-dependent cell-mediated cytotoxicity (ADCC) is one mechanism of action
of the monoclonal antibody (mAb) therapies trastuzumab and pertuzumab. Tyrosine kinase …
of the monoclonal antibody (mAb) therapies trastuzumab and pertuzumab. Tyrosine kinase …
The root cause of drug resistance in HER2-positive breast cancer and the therapeutic approaches to overcoming the resistance
Y Zhang - Pharmacology & therapeutics, 2021 - Elsevier
HER2 is a well-known oncogenic receptor tyrosine kinase. HER2 gene amplification occurs
in about 20% of breast cancer (BC), which leads to overexpression of HER2 protein, known …
in about 20% of breast cancer (BC), which leads to overexpression of HER2 protein, known …
The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers
LC Zanetti-Domingues, D Korovesis… - Nature …, 2018 - nature.com
Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is
based on X-ray structural data of monomer and dimer receptor fragments and does not …
based on X-ray structural data of monomer and dimer receptor fragments and does not …
Tracing the origin and evolution of pseudokinases across the tree of life
Protein phosphorylation by eukaryotic protein kinases (ePKs) is a fundamental mechanism
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
of cell signaling in all organisms. In model vertebrates,~ 10% of ePKs are classified as …
Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2 …
An estimated 15–20% of breast cancers overexpress human epidermal growth factor
receptor 2 (HER2/ERBB2/neu). Two small-molecule tyrosine kinase inhibitors (TKIs) …
receptor 2 (HER2/ERBB2/neu). Two small-molecule tyrosine kinase inhibitors (TKIs) …
It takes more than two to tango: Complex, hierarchal, and membrane-modulated interactions in the regulation of receptor tyrosine kinases
Simple Summary Receptor tyrosine kinases probably constitute the most important
subfamily of transmembrane receptors with respect to their role in regulating the balance …
subfamily of transmembrane receptors with respect to their role in regulating the balance …