Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease

L Amirifar, A Shamloo, R Nasiri, NR de Barros… - Biomaterials, 2022 - Elsevier
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

Recurrent urinary tract infection: a mystery in search of better model systems

BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

L Si, H Bai, M Rodas, W Cao, CY Oh, A Jiang… - Nature biomedical …, 2021 - nature.com
The rapid repurposing of antivirals is particularly pressing during pandemics. However,
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …

Mechanical stimulation: a crucial element of organ-on-chip models

CL Thompson, S Fu, HK Heywood… - … in bioengineering and …, 2020 - frontiersin.org
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

[HTML][HTML] Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity

DA Hoagland, R Møller, SA Uhl, K Oishi, J Frere… - Immunity, 2021 - cell.com
The emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has resulted in significant global morbidity, mortality, and societal disruption. A better …

[HTML][HTML] Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses

MA Schaller, Y Sharma, Z Dupee, D Nguyen… - JCI insight, 2021 - ncbi.nlm.nih.gov
Cell lines are the mainstay in understanding the biology of COVID-19 infection but do not
recapitulate many of the complexities of human infection. The use of human lung tissue is …

In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

M Kiener, N Roldan, C Machahua, A Sengupta… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …

[HTML][HTML] Gut-on-Chip microphysiological systems: Latest advances in the integration of sensing strategies and adoption of mature detection mechanisms

MA Signore, C De Pascali, L Giampetruzzi… - Sensing and Bio …, 2021 - Elsevier
Synergic efforts in microfabrication processes, cells culture and tissue engineering promoted
extraordinary progress in Organ-on-Chip (OoC) technology, leading to the development of in …

Experimental models of SARS-CoV-2 infection: possible platforms to study COVID-19 pathogenesis and potential treatments

S Pandamooz, B Jurek, CP Meinung… - Annual review of …, 2022 - annualreviews.org
In December 2019, a novel coronavirus crossed species barriers to infect humans and was
effectively transmitted from person to person, leading to a worldwide pandemic …