New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …

Disease overview The eosinophilias encompass a broad range of non‐hematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …

Adoptive T cell therapies have produced exceptional responses in a subset of patients with
cancer. However, therapeutic efficacy can be hindered by poor T cell persistence and …

Abstract Disease Overview The eosinophilias encompass a broad range of nonhematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …

Evans syndrome (ES) is a rare severe autoimmune disorder characterized by the
combination of autoimmune hemolytic anemia and immune thrombocytopenia. In most …

Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular
signaling pathway is utilized by many proinflammatory molecules to mediate downstream …

Primary immunodeficiencies (PIDs) comprise a diverse group of over 400 genetic disorders
that result in clinically apparent immune dysfunction. Although PIDs are classically …

Eosinophilic-related clinical manifestations are protean and the underlying conditions
underpinning eosinophilia are highly diverse. The etiological workup of unexplained …

Somatic, gain-of-function mutations in STAT3 and STAT5 have been described in leukemias
and lymphomas1-6 and, more recently, in CD3-CD4 1 T cells from a patient with lymphocytic …