In recent years the status of the inflammatory bowel diseases (IBDs) as canonical
autoimmune diseases has risen steadily with the recognition that these diseases are, at their …

There are now many experimental models of inflammatory bowel disease (IBD), most of
which are due to induced mutations in mice that result in an impaired homeostasis with the …

The physiologic role of the μ opioid receptor (MOR) in gut nociception, motility, and secretion
is well established. To evaluate whether MOR may also be involved in controlling gut …

Regulatory T (Treg) cells, which maintain immune homeostasis and self-tolerance, form an
immunological synapse (IS) with antigen-presenting cells (APCs). However, signaling …

Autoimmune diseases are characterized by dysfunctional immune systems that
misrecognize self as non‐self and cause tissue destruction. Several cell types have been …

The interaction between the tumor necrosis factor (TNF) family member LIGHT and the TNF
family receptor herpes virus entry mediator (HVEM) co-stimulates T cells and promotes …

It is well recognized that the composition of the mature T cell population is subject to strict
homeostatic control. The TCR repertoire and relative proportions of various T cell subsets …

The common mucosal immune system (CMIS) consists of an integrated cross‐
communication pathway of lymphoid tissues made up of inductive and effector sites for host …

Mammals are highly adapted to their very high densities of non-pathogenic bacteria which
inhabit the lower small intestine and colon. This is achieved by a series of functional and …

T cell clonal expansions are present in the inflamed mucosa of patients with Crohn's disease
(CD) and may be implicated in postoperative recurrence after ileocolonic resection. Methods …