Aripiprazole, brexpiprazole and cariprazine differ from all other second-generation
antipsychotics due to partial agonism at the dopamine D2 and D3 receptors. In contrast to …

Efflux transport systems are essential to suppress the absorption of xenobiotics from the
intestinal lumen and protect the critical tissues at the blood-tissue barriers, such as the blood …

Some histamine H1 receptor (H1R) antagonists induce adverse sedative reactions caused
by blockade of histamine transmission in the brain. Desloratadine is a second‐generation …

Varenicline is a selective partial α 4 β 2 nicotinic acetylcholine receptor agonist, which is
used to help achieve smoking cessation. Here, we investigated varenicline transport at the …

Introduction Chronic spontaneous urticaria (CSU) is characterized by urticaria persisting for
more than 6 weeks and leading to significant morbidity. Antihistamines, especially sgAH …

At present, there are many kinds of H 1 receptor antagonists as medicinal foods in clinical
application, which can be divided into ethylenediamine antagonist, aminoether antagonist …

Background Rituximab, an anti-CD20 monoclonal antibody, can cause infusion reactions
(IRs), especially during the initial rituximab infusion therapy. Generally, patients are …

The binding affinity of ligands for their receptors is determined by their kinetic and
thermodynamic binding properties. Kinetic analyses of the rate constants of association and …

抄録 血液と脳組織との間には脳毛細血管内皮細胞 (brain microvascular endothelial cell:
BMEC) を実体とする血液脳関門 (blood brain barrier: BBB) が存在し, 血液と脳組織の間で行 …