An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

The spectrum of non-alcoholic fatty liver disease (NAFLD) ranges from simple hepatic
steatosis, commonly associated with obesity, to non-alcoholic steatohepatitis, which can …

Background The gut‐liver axis is considered to play a critical role in the development and
progression of nonalcoholic fatty liver disease (NAFLD). The integrity of the epithelial barrier …

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Childhood obesity has become a global epidemic and carries significant long‐term
consequences to physical and mental health. Metabolomics, the global profiling of small …

Non-alcoholic fatty liver disease (NAFLD) is the most frequent type of chronic liver disease in
the pediatric age group, paralleling an obesity pandemic. A “multiple-hit” hypothesis has …

The prevalence of overweight and obesity in children and adolescents is an increasing
public health problem. Pediatric overweight and obesity result from multiple factors …

Betaine is a kind of water-soluble quaternary amine-type alkaloid widely existing in food,
such as wheat germ, beet, spinach, shrimp and wolfberry. As an important methyl donor and …

Numerous studies have described specific metabolites as biomarkers of severe liver
diseases, but very few have measured gut microbiota (GM)-produced metabolites in fatty …

Abstract Introduction Non-Alcoholic Fatty Liver Disease encompasses a spectrum of
diseases ranging from simple steatosis to steatohepatitis (or NASH), up to cirrhosis and …