The exon junction complex as a node of post-transcriptional networks
HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
The role of TREX in gene expression and disease
CG Heath, N Viphakone, SA Wilson - Biochemical Journal, 2016 - portlandpress.com
TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts
T Di Mattia, A Martinet, S Ikhlef, AG McEwen… - The EMBO …, 2020 - embopress.org
Organelles are physically connected by membrane contact sites. The endoplasmic reticulum
possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins …
possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins …
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex
J Saulière, V Murigneux, Z Wang… - Nature structural & …, 2012 - nature.com
The exon junction complex (EJC) is a central effector of the fate of mRNAs, linking nuclear
processing to mRNA transport, translation and surveillance. However, little is known about …
processing to mRNA transport, translation and surveillance. However, little is known about …
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction
complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay …
complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay …
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
D Overwijn, M Hondele - Trends in Biochemical Sciences, 2023 - cell.com
RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
A day in the life of the exon junction complex
LP Schlautmann, NH Gehring - Biomolecules, 2020 - mdpi.com
The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP)
component that is assembled during splicing and binds to mRNAs upstream of exon-exon …
component that is assembled during splicing and binds to mRNAs upstream of exon-exon …
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis
Exon junction complexes (EJCs) mark untranslated spliced mRNAs and are crucial for the
mRNA lifecycle. An imbalance in EJC dosage alters mouse neural stem cell (mNSC) …
mRNA lifecycle. An imbalance in EJC dosage alters mouse neural stem cell (mNSC) …
The exon junction complex undergoes a compositional switch that alters mRNP structure and nonsense-mediated mRNA decay activity
The exon junction complex (EJC) deposited upstream of mRNA exon junctions shapes
structure, composition, and fate of spliced mRNA ribonucleoprotein particles (mRNPs). To …
structure, composition, and fate of spliced mRNA ribonucleoprotein particles (mRNPs). To …