[HTML][HTML] Advancing personalized medicine through the application of whole exome sequencing and big data analytics

P Suwinski, CK Ong, MHT Ling, YM Poh… - Frontiers in …, 2019 - frontiersin.org
There is a growing attention toward personalized medicine. This is led by a fundamental
shift from the 'one size fits all'paradigm for treatment of patients with conditions or …

[HTML][HTML] A genomic information management system for maintaining healthy genomic states and application of genomic big data in clinical research

JA Gim - International Journal of Molecular Sciences, 2022 - mdpi.com
Improvements in next-generation sequencing (NGS) technology and computer systems
have enabled personalized therapies based on genomic information. Recently, health …

A cell‐free DNA barcode‐enabled single‐molecule test for noninvasive prenatal diagnosis of monogenic disorders: application to β‐thalassemia

X Yang, Q Zhou, W Zhou, M Zhong, X Guo… - Advanced …, 2019 - Wiley Online Library
Noninvasive prenatal testing of common aneuploidies has become routine over the past
decade, but testing of monogenic disorders remains a challenge in clinical implementation …

[HTML][HTML] Developing a reproducible microbiome data analysis pipeline using the Amazon web services cloud for a cancer research group: proof-of-concept study

J Bai, I Jhaney, J Wells - JMIR medical informatics, 2019 - medinform.jmir.org
Background: Cloud computing for microbiome data sets can significantly increase working
efficiencies and expedite the translation of research findings into clinical practice. The …

[HTML][HTML] Design and implementation of a hybrid cloud system for large-scale human genomic research

M Nagasaki, Y Sekiya, A Asakura, R Teraoka… - Human Genome …, 2023 - nature.com
In the field of genomic medical research, the amount of large-scale information continues to
increase due to advances in measurement technologies, such as high-performance …

Rabbitfx: efficient framework for fasta/q file parsing on modern multi-core platforms

H Zhang, H Song, X Xu, Q Chang… - IEEE/ACM …, 2022 - ieeexplore.ieee.org
The continuous growth of generated sequencing data leads to the development of a variety
of associated bioinformatics tools. However, many of them are not able to fully exploit the …

[HTML][HTML] Improving read alignment through the generation of alternative reference via iterative strategy

L Bu, Q Wang, W Gu, R Yang, D Zhu, Z Song, X Liu… - Scientific Reports, 2020 - nature.com
There is generally one standard reference sequence for each species. When extensive
variations exist in other breeds of the species, it can lead to ambiguous alignment and …

Bioinformatics: Unveiling the Systems Biology

A Kumar, SF Ahmad - Biotechnological Interventions Augmenting …, 2023 - Springer
The human population is continuously increasing, and food production has to keep pace
ensuring food and nutritional security. Genetics and biotechnology fields have played a …

TAXAPRO: A Streamlined Pipeline to Analyze Shotgun Metagenomes

S Sehli, Z El Ouafi, C Eddington, S Jbara… - … on Advanced Intelligent …, 2023 - Springer
Background: The ability to promptly sequence whole genomes at a relatively low cost has
revolutionized how we study the microbiome. Analyzing whole genome sequencing (WGS) …

Check for updates TAXAPRO: A Streamlined Pipeline to Analyze Shotgun Metagenomes

S Sehli¹, Z El Ouafi¹, C Eddington, S Jbara… - … Systems on Digital …, 2024 - books.google.com
Background: The ability to promptly sequence whole genomes at a relatively low cost has
revolutionized how we study the microbiome. Analyzing whole genome sequencing (WGS) …