The importance of EZH2 as a key methyltransferase has been well documented
theoretically. Practically, the first EZH2 inhibitor Tazemetostat (EPZ6438), was approved by …

Scarring, which develops due to fibroblast activation and excessive extracellular matrix
deposition, can cause physical, psychological, and cosmetic problems. Fibroblasts are the …

E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent
binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and …

Fibrous dysplasia (FD) is a rare bone disorder characterized by the replacement of normal
bone with benign fibro-osseous tissue. Developments in our understanding of the …

Smad ubiquitin regulatory factor 2 (Smurf2), an essential negative regulator of TGF-β
signaling, ubiquitinates TGF-β receptors (TβRs) and Smad proteins, inducing their …

Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is implicated in the control of
multiple essential processes, including transcription, DNA damage repair and mitotic …

F-box/LRR-repeat protein 7 (FBXL7) was predicted as a differentially expressed E3 ubiquitin
ligase in non-small cell lung cancer (NSCLC), which has been suggested to influence …

Overexpression of HECT-type E3 ubiquitin ligase SMURF1 is correlated with poor prognosis
in patients with various cancers, such as glioblastoma, colon cancer, and clear cell renal cell …

Dysregulated angiogenesis of mesenchymal stem cells (MSCs) is closely related to
inflammation and disrupted bone metabolism in patients with various autoimmune diseases …

Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the
regulation of a plethora of molecular and cellular processes. These include the nuclear …