Improved biomarker discovery through a plot twist in transcriptomic data analysis

N Sánchez-Baizán, L Ribas, F Piferrer - BMC biology, 2022 - Springer
Background Transcriptomic analysis is crucial for understanding the functional elements of
the genome, with the classic method consisting of screening transcriptomics datasets for …

A machine learning analysis of health records of patients with chronic kidney disease at risk of cardiovascular disease

D Chicco, CA Lovejoy, L Oneto - IEEE Access, 2021 - ieeexplore.ieee.org
Chronic kidney disease (CKD) describes a long-term decline in kidney function and has
many causes. It affects hundreds of millions of people worldwide every year. It can have a …

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

A Gholaminejad, M Fathalipour, A Roointan - BMC nephrology, 2021 - Springer
Background Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and
leading cause of end-stage renal disease. The underlying molecular mechanism of DN is …

Construction and evaluation of an integrated predictive model for chronic kidney disease based on the random forest and artificial neural network approaches

Y Zhou, Z Yu, L Liu, L Wei, L Zhao, L Huang… - Biochemical and …, 2022 - Elsevier
Chronic kidney disease (CKD) is recognized as a serious global health problem due to its
high prevalence and all-cause mortality. The aim of this research was to identify critical …

Weighted gene Co-expression network analysis (WGCNA) reveals a set of hub genes related to chlorophyll metabolism process in chlorella (Chlorella vulgaris) …

H Yu, X Du, Q Zhao, C Yin, W Song - Environmental Pollution, 2022 - Elsevier
Androstenedione (ADSD) was the main androgen detected in wastewaters. Chlorella was
the most widely used plant in biological wastewater treatment process. In order to …

Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA

WX Xia, Q Yu, GH Li, YW Liu, FH Xiao, LQ Yang… - PeerJ, 2019 - peerj.com
Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignant cancer in
the adrenal cortex with poor prognosis. Though previous research has attempted to …

[HTML][HTML] MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes

H Yamada, N Shirata, S Makino, T Miyake, JAO Trejo… - Kidney International, 2021 - Elsevier
Podocytes are highly specialized cells within the glomerulus that are essential for
ultrafiltration. The slit-diaphragm between the foot processes of podocytes functions as a …

Comprehensive genetic analysis of tuberculosis and identification of candidate biomarkers

Z Wen, L Wu, L Wang, Q Ou, H Ma, Q Wu… - Frontiers in …, 2022 - frontiersin.org
Purpose: The purpose of this study is to use the data in the GEO database to analyze,
screen biomarkers that can diagnose tuberculosis, and verification of candidate biomarkers …

Weighted correlation network bioinformatics uncovers a key molecular biosignature driving the left-sided heart failure

J Zhou, W Zhang, C Wei, Z Zhang, D Yi, X Peng… - BMC Medical …, 2020 - Springer
Background Left-sided heart failure (HF) is documented as a key prognostic factor in HF.
However, the relative molecular mechanisms underlying left-sided HF is unknown. The …

Interstitial HIF1A induces an estimated glomerular filtration rate decline through potentiating renal fibrosis in diabetic nephropathy

X Li, S Yang, M Yan, N Guan, J Li, Q Xie, C Hao - Life sciences, 2020 - Elsevier
Aims This study aimed to identify interstitial molecules that were responsible for the
deterioration of the esiantimated glomerular filtration rate (eGFR) in diabetic nephropathy …