Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

Perinatal nutritional and metabolic pathways: early origins of chronic lung diseases

C Kuiper-Makris, J Selle, E Nüsken, J Dötsch… - Frontiers in …, 2021 - frontiersin.org
Lung development is not completed at birth, but expands beyond infancy, rendering the lung
highly susceptible to injury. Exposure to various influences during a critical window of organ …

Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life

J Selle, K Dinger, V Jentgen, D Zanetti, J Will… - Nature …, 2022 - nature.com
Obesity is a pre-disposing condition for chronic obstructive pulmonary disease, asthma, and
pulmonary arterial hypertension. Accumulating evidence suggests that metabolic influences …

PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis

H He, J Chen, J Zhao, P Zhang, Y Qiao, H Wan… - Cell death & …, 2021 - nature.com
Although aberrant alveolar myofibroblasts (AMYFs) proliferation and differentiation are often
associated with abnormal lung development and diseases, such as bronchopulmonary …

Asthma prevalence, lung and cardiovascular function in adolescents born preterm

M Arroyas, C Calvo, S Rueda, M Esquivias… - Scientific Reports, 2020 - nature.com
Our main objective was to study respiratory evolution and pulmonary and cardiac function in
adolescents born preterm in the post-surfactant era. Observational cross-sectional study …

Perinatal origins of bronchopulmonary dysplasia—deciphering normal and impaired lung development cell by cell

I Mižíková, B Thébaud - Molecular and Cellular Pediatrics, 2023 - Springer
Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence
of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD …

Dynamic regulation of GH–IGF1 signaling in injury and recovery in hyperoxia-induced neonatal lung injury

C Vohlen, J Mohr, A Fomenko, C Kuiper-Makris… - Cells, 2021 - mdpi.com
Prematurely born infants often require supplemental oxygen that impairs lung growth and
results in arrest of alveolarization and bronchopulmonary dysplasia (BPD). The growth …

Uteroplacental insufficiency decreases leptin expression and impairs lung development in growth-restricted newborn rats

ME Yuliana, HC Chou, ECY Su, HC Chuang… - Pediatric …, 2024 - nature.com
Background The study aimed to analyze the effect of uteroplacental insufficiency (UPI) on
leptin expression and lung development of intrauterine growth restriction (IUGR) rats …

Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats

R Khazaee, LA McCaig, C Yamashita, DB Hardy… - PLoS …, 2019 - journals.plos.org
Limited information is available on how fetal growth retardation (FGR) affects the lung in the
neonatal period in males and females. This led us to test the hypothesis that FGR alters lung …

Inducible factors and interaction of pulmonary fibrosis induced by prenatal dexamethasone exposure in offspring rats

Z Zhang, H Chen, P Yu, C Ge, M Fang, X Zhao… - Toxicology Letters, 2022 - Elsevier
This study aimed to investigate the correlation between prenatal dexamethasone exposure
(PDE) and susceptibility to pulmonary fibrosis in offspring. Healthy female Wistar rats were …