Interaction modules that impart specificity to disordered protein
K Cermakova, HC Hodges - Trends in biochemical sciences, 2023 - cell.com
Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …
Compendium of human transcription factor effector domains
Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …
modulating transcriptional activity through their effector domains. Despite the central role of …
Large-scale mapping and mutagenesis of human transcriptional effector domains
Human gene expression is regulated by more than 2,000 transcription factors and chromatin
regulators,. Effector domains within these proteins can activate or repress transcription …
regulators,. Effector domains within these proteins can activate or repress transcription …
An activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a
relationship between these two features exists is unclear. Here we provide evidence for an …
relationship between these two features exists is unclear. Here we provide evidence for an …
[HTML][HTML] Directed mutational scanning reveals a balance between acidic and hydrophobic residues in strong human activation domains
MV Staller, E Ramirez, SR Kotha, AS Holehouse… - Cell systems, 2022 - cell.com
Acidic activation domains are intrinsically disordered regions of the transcription factors that
bind coactivators. The intrinsic disorder and low evolutionary conservation of activation …
bind coactivators. The intrinsic disorder and low evolutionary conservation of activation …
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
AL Sanborn, BT Yeh, JT Feigerle, CV Hao… - Elife, 2021 - elifesciences.org
Gene activator proteins comprise distinct DNA-binding and transcriptional activation
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …
Identification and functional characterization of transcriptional activators in human cells
Transcription is orchestrated by thousands of transcription factors (TFs) and chromatin-
associated proteins, but how these are causally connected to transcriptional activation is …
associated proteins, but how these are causally connected to transcriptional activation is …
Identification of plant transcriptional activation domains
Gene expression in Arabidopsis is regulated by more than 1,900 transcription factors (TFs),
which have been identified genome-wide by the presence of well-conserved DNA-binding …
which have been identified genome-wide by the presence of well-conserved DNA-binding …
High-throughput discovery and characterization of human transcriptional effectors
Thousands of proteins localize to the nucleus; however, it remains unclear which contain
transcriptional effectors. Here, we develop HT-recruit, a pooled assay where protein libraries …
transcriptional effectors. Here, we develop HT-recruit, a pooled assay where protein libraries …
Artificial intelligence and machine learning in precision medicine: A paradigm shift in big data analysis
The integration of artificial intelligence in precision medicine has revolutionized healthcare
delivery. Precision medicine identifies the phenotype of particular patients with less-common …
delivery. Precision medicine identifies the phenotype of particular patients with less-common …