Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Germline activating mutations of the protein tyrosine phosphatase SHP2 (encoded by
PTPN11), a positive regulator of the RAS signalling pathway, are found in 50% of patients …

The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …

Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …

We report a Jak2V617F knockin mouse myeloproliferative neoplasm (MPN) model
resembling human polycythemia vera (PV). The MPN is serially transplantable and we …

Deregulation of signaling pathways, through mutation or other molecular changes, can
ultimately result in disease. The tyrosine phosphatase Shp2 has emerged as a major …

Hematopoietic stem cells (HSC) reside in the bone marrow (BM) within a specialized micro-
environment, the HSC niche, which comprises several cellular constituents. These include …

Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden death in children and
young adults. Abnormalities in several signaling pathways are implicated in the …

Myeloid neoplasms derive from the pathological clonal expansion of an abnormal stem cell
and span a diverse spectrum of phenotypes including acute myeloid leukaemia (AML) …