Fusobacterium nucleatum and oral cancer: a critical review

E McIlvanna, GJ Linden, SG Craig, FT Lundy… - BMC cancer, 2021 - Springer
There is a growing level of interest in the potential role inflammation has on the initiation and
progression of malignancy. Notable examples include Helicobacter pylori-mediated …

Immune system, microbiota, and microbial metabolites: the unresolved triad in colorectal cancer microenvironment

M Hanus, D Parada-Venegas, G Landskron… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is one of the most common cancers worldwide. As with other
cancers, CRC is a multifactorial disease due to the combined effect of genetic and …

[HTML][HTML] Fusobacterium nucleatum and colorectal cancer: A review

FM Shang, HL Liu - World journal of gastrointestinal oncology, 2018 - ncbi.nlm.nih.gov
Fusobacterium nucleatum (F. nucleatum) is a Gram-negative obligate anaerobe bacterium
in the oral cavity and plays a role in several oral diseases, including periodontitis and …

[HTML][HTML] The role of Fusobacterium nucleatum in oral and colorectal carcinogenesis

P Pignatelli, F Nuccio, A Piattelli, MC Curia - Microorganisms, 2023 - mdpi.com
In recent years, several studies have suggested a strong association of microorganisms with
several human cancers. Two periodontopathogenic species in particular have been …

[HTML][HTML] Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade

Y Chen, Y Peng, J Yu, T Chen, Y Wu, L Shi, Q Li, J Wu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The underlying mechanism of Fusobacterium nucleatum (Fn) in the carcinogenesis of
colorectal cancer (CRC) is poorly understood. Here, we examined Fn abundance in CRC …

Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?

KQ De Andrade, CLC Almeida-da-Silva… - Mediators of …, 2019 - Wiley Online Library
Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are
Gram‐negative anaerobic bacteria possessing several virulence factors that make them …

Fusobacterium and Enterobacteriaceae: important players for CRC?

E Allen-Vercoe, C Jobin - Immunology letters, 2014 - Elsevier
The gut microbiota plays an essential role in regulating intestinal homeostasis through its
capacity to modulate various biological activities ranging from barrier, immunity and …

[HTML][HTML] Microbiome and colorectal carcinogenesis: linked mechanisms and racial differences

SC Tortora, VM Bodiwala, A Quinn… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Various studies have shown the interplay between the intestinal microbiome, environmental
factors, and genetic changes in colorectal cancer (CRC) development. In this review, we …

Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer

SA Lee, F Liu, SM Riordan, CS Lee, L Zhang - Frontiers in oncology, 2019 - frontiersin.org
Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality.
Emerging evidence from recent studies suggests a potential role of Fusobacterium …

NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection

SC Hung, PR Huang, CLC Almeida-da-Silva… - Microbes and …, 2018 - Elsevier
NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their
role in periodontitis remains to be defined. NLRX1, a member of the NLR family that …