Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

There has been increasing emphasis on the importance of the development of self-
regulatory capacities of the individual as the cornerstone of development. The caregivers' …

Importance High-risk infants, defined as newborns with substantial neonatal-perinatal
morbidities, often undergo multiple procedures and require prolonged intubation, resulting …

The opioid epidemic has adversely affected neonates and children, yet the mechanisms by
which it impacts this population are not well understood. Not only does prenatal opioid …

Background Preclinical data demonstrate that opioids modulate brain reward signaling
through an inflammatory cascade, but this relationship has yet to be studied in opioid …

Importance Prenatal opioid exposure (POE) may alter with fetal development of the immune
system, which may influence long-term health and susceptibility to immune-related …

Aim: To define a developmental trajectory in infants with neonatal opioid withdrawal
syndrome (NOWS) and determine whether the impacted developmental domain varies with …

Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …

Importance Necrotizing enterocolitis (NEC) requiring surgical intervention is the most
common reason for surgical procedures in preterm neonates. Opioids are used to manage …

Excessive prenatal opioid exposure may lead to the development of Neonatal Opioid
Withdrawal Syndrome (NOWS). RNA-seq was done on 64 formalin-fixed paraffin-embedded …