Interactions between HIV proteins and host restriction factors: implications for potential therapeutic intervention in HIV infection
Different host proteins target different HIV proteins and antagonize their functions,
depending on the stage of the HIV life cycle and the stage of infection. Concurrently, HIV …
depending on the stage of the HIV life cycle and the stage of infection. Concurrently, HIV …
Beyond Impairment of Virion Infectivity: New Activities of the Anti-HIV Host Cell Factor SERINC5
S Sid Ahmed, K Bajak, OT Fackler - Viruses, 2024 - mdpi.com
Members of the serine incorporator (SERINC) protein family exert broad antiviral activity,
and many viruses encode SERINC antagonists to circumvent these restrictions. Significant …
and many viruses encode SERINC antagonists to circumvent these restrictions. Significant …
[HTML][HTML] HIV Nef expression down-modulated GFAP expression and altered glutamate uptake and release and proliferation in astrocytes
KM Wilson, JJ He - Aging and disease, 2023 - ncbi.nlm.nih.gov
HIV infection of astrocytes leads to restricted gene expression and replication but abundant
expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so …
expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so …
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our
understanding of how naturally occurring global Nef sequence diversity impacts these …
understanding of how naturally occurring global Nef sequence diversity impacts these …
HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity
Q Chai, S Li, MK Collins, R Li, I Ahmad, SF Johnson… - Cell reports, 2021 - cell.com
Summary HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5)
by redirecting this potent restriction factor to the endosomes and lysosomes for degradation …
by redirecting this potent restriction factor to the endosomes and lysosomes for degradation …
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The
role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 …
role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 …
Differential Pressures of SERINC5 and IFITM3 on HIV-1 Envelope Glycoprotein over the Course of HIV-1 Infection
Infection of human immunodeficiency virus type 1 (HIV-1) is subject to restriction by cellular
factors. Serine incorporator 5 (SERINC5) and interferon-inducible transmembrane 3 …
factors. Serine incorporator 5 (SERINC5) and interferon-inducible transmembrane 3 …
Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction
S Li, R Li, I Ahmad, X Liu, SF Johnson, L Sun… - Nature …, 2022 - nature.com
HIV-1 must counteract various host restrictions to establish productive infection. SERINC5 is
a potent restriction factor that blocks HIV-1 entry from virions, but its activity is counteracted …
a potent restriction factor that blocks HIV-1 entry from virions, but its activity is counteracted …
HIV-1 restriction by SERINC5
L Cano-Ortiz, T Luedde, C Münk - Medical Microbiology and Immunology, 2023 - Springer
Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-
defined cellular activities. SER5 was recently described as a human immunodeficiency virus …
defined cellular activities. SER5 was recently described as a human immunodeficiency virus …
An amino acid polymorphism within the HIV-1 Nef dileucine motif functionally uncouples cell surface CD4 and SERINC5 downregulation
MJ Mumby, AL Johnson, SM Trothen… - Journal of …, 2021 - Am Soc Microbiol
ABSTRACT Serine incorporator 5 (SERINC5) reduces the infectivity of progeny HIV-1 virions
by incorporating into the outer host-derived viral membrane during egress. To counter …
by incorporating into the outer host-derived viral membrane during egress. To counter …