Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk
A Contursi, S Tacconelli, U Hofling, A Bruno… - Biochemical …, 2022 - Elsevier
Abstract Platelet-type lipoxygenase (pl12-LOX), encoded by ALOX12, catalyzes the
production of the lipid mediator 12S-hydroperoxyeicosa-5, 8, 10, 14-tetraenoic acid (12S …
production of the lipid mediator 12S-hydroperoxyeicosa-5, 8, 10, 14-tetraenoic acid (12S …
20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance
A Gilani, K Agostinucci, S Hossain, JV Pascale… - Prostaglandins & other …, 2021 - Elsevier
HETE, a metabolite of arachidonic acid produced by Cytochrome P450 (CYP) 4A/4 F, has
been implicated in the development of obesity-associated complications such as diabetes …
been implicated in the development of obesity-associated complications such as diabetes …
High-fat diet-induced obesity and insulin resistance in CYP4a14−/− mice is mediated by 20-HETE
20-Hydroxyeicosatetraenoic acid (20-HETE) has been shown to positively correlate with
body mass index, hyperglycemia, and plasma insulin levels. This study seeks to identify a …
body mass index, hyperglycemia, and plasma insulin levels. This study seeks to identify a …
[HTML][HTML] Conflicting roles of 20-HETE in hypertension and renal end organ damage
HETE is a cytochrome P450-derived metabolite of arachidonic acid that has both pro-and
anti-hypertensive actions that result from modulation of vascular and kidney function. In the …
anti-hypertensive actions that result from modulation of vascular and kidney function. In the …
Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate
S Satarug, K Boonprasert, GC Gobe… - Clinical Kidney …, 2019 - academic.oup.com
Abstract Background Urinary 20-hydroxyeicosatetraenoic acid (20-HETE) has been
associated with hypertension in women with elevated urinary cadmium (Cd) excretion rates …
associated with hypertension in women with elevated urinary cadmium (Cd) excretion rates …
Effects of nonsteroidal anti-inflammatory drugs on the expression of arachidonic acid-metabolizing Cyp450 genes in mouse hearts, kidneys and livers
Arachidonic acid (ARA) metabolites are involved in cardiovascular diseases and drug-
induced cardiotoxicity. The present study aimed to investigate the effects of nonsteroidal anti …
induced cardiotoxicity. The present study aimed to investigate the effects of nonsteroidal anti …
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation
A Soler, I Hunter, G Joseph, R Hutcheson… - Journal of molecular and …, 2018 - Elsevier
Arterial stiffness plays a causal role in development of systolic hypertension. 20-
hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic …
hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic …
The CYP/20-HETE/GPR75 axis in hypertension
Hydroxyeicosatetraenoic acid (20-HETE) is a bioactive lipid generated from the ω-
hydroxylation of arachidonic acid (AA) by enzymes of the cytochrome P450 (CYP) family …
hydroxylation of arachidonic acid (AA) by enzymes of the cytochrome P450 (CYP) family …
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of …
K Agostinucci, R Hutcheson, S Hossain… - Journal of …, 2022 - journals.lww.com
Objective: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a vasoactive eicosanoid exhibiting
effects on vascular smooth muscle cell (VSMC) via G-protein coupled receptor 75 (GPR75) …
effects on vascular smooth muscle cell (VSMC) via G-protein coupled receptor 75 (GPR75) …