Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via
VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when …

Aims KCNQ1 and KCNE1 encode Kv7. 1 and KCNE1, respectively, the pore-forming and the
accessory subunits of the slow delayed rectifier potassium current, I Ks. KCNQ1 mutations …

Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate
(IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In …

Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic
KV 7.1 and KV 7.1+ KCNE1 channel activators. In this study, we describe dual independent …

SeSAME/EAST syndrome is a channelopathy consisting of a hypokalemic,
hypomagnesemic, metabolic alkalosis associated with seizures, sensorineural deafness …

KCNQ1 is a pore-forming K+ channel subunit critically important to cardiac repolarization at
high heart rates.(2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl) sulfonyl]-2 …

Loss-of-function mutations in Kv7. 1 often lead to long QT syndrome (LQTS), a cardiac
repolarization disorder associated with arrhythmia and subsequent sudden cardiac death …

In vivo, KCNQ1 α-subunits associate with the β-subunit KCNE1 to generate the slowly
activating cardiac potassium current (I Ks). Structurally, they share their topology with other …