General pathways of pain sensation and the major neurotransmitters involved in pain regulation
Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
Cannabinoid ligands targeting TRP channels
Transient receptor potential (TRP) channels are a group of membrane proteins involved in
the transduction of a plethora of chemical and physical stimuli. These channels modulate ion …
the transduction of a plethora of chemical and physical stimuli. These channels modulate ion …
New approaches and challenges to targeting the endocannabinoid system
V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization
O Gouin, K L'herondelle, N Lebonvallet… - Protein & …, 2017 - academic.oup.com
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …
[HTML][HTML] The endocannabinoid system and its modulation by phytocannabinoids
V Di Marzo, F Piscitelli - Neurotherapeutics, 2015 - Elsevier
The endocannabinoid system is currently defined as the ensemble of the two 7-
transmembrane-domain and G protein-coupled receptors for Δ 9-tetrahydrocannabinol (but …
transmembrane-domain and G protein-coupled receptors for Δ 9-tetrahydrocannabinol (but …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
[图书][B] Endocannabinoids and their pharmacological actions
RG Pertwee - 2015 - Springer
The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …
receptors, of endogenous compounds known as endocannabinoids that can target these …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) …
FA Iannotti, CL Hill, A Leo, A Alhusaini… - ACS chemical …, 2014 - ACS Publications
Epilepsy is the most common neurological disorder, with over 50 million people worldwide
affected. Recent evidence suggests that the transient receptor potential cation channel …
affected. Recent evidence suggests that the transient receptor potential cation channel …
[HTML][HTML] Endocannabinoid-mediated control of synaptic transmission
M Kano, T Ohno-Shosaku… - Physiological …, 2009 - journals.physiology.org
The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …