Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

S. cerevisiae chromosomes end with the telomeric repeat (TG,-&. When any of four Pol II
genes was placed immediately adjacent to the telomeric repeats, expression of the gene …

Chromatin instability and mitochondrial decline are conserved processes that contribute to
cellular aging. Although both processes have been explored individually in the context of …

Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is
known about conserved mechanisms of silencing. We report here the discovery of four …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

Genes placed near telomeres in S. cerevisiae succumb to position-effect variegation. SIR2,
SlR3, SIR4, NATl, ARD7, and HHF2 (histone H4) were identified as modifiers of the position …

The yeast RAP1 protein is a sequence-specific DNA-binding protein that functions as both a
repressor and an activator of transcription. RAP1 is also involved in the regulation of …

Two classes of sequences in the yeast Saccharomyces cerevisiae are subject to
transcriptional silencing: the silent mating-type cassettes and telomeres. In this report we …

The maintenance of transcriptional silencing at HM mating-type loci and telomeres in yeast
requires the SIR2, SIR3, and SIR4 proteins, none of which appear to be DNA-binding …