Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …

Aging is a complex phenomenon characterized by the progressive loss of tissue and organ
function. The oxidative-stress theory of aging postulates that age-associated functional …

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …

Non-alcoholic fatty liver disease (NAFLD) is a major global health threat due to its growing
incidence and prevalence. It is becoming the leading cause of liver disease in addition to its …

Polyunsaturated fatty acids (PUFA) play essential roles in cell membrane structure and
physiological processes including signal transduction, cellular metabolism and tissue …

Mineral oil is often used as a clinical trial placebo. Pharmaceutical-grade mineral oil consists
of a mixture of saturated hydrocarbons, with a purity and chemical structure that differs …

For many years it has been known that high doses of long chain omega-3 fatty acids are
beneficial in the treatment of hypertriglyceridaemia. Over the last three decades, there has …

Background: Clinical trials examining the therapeutic benefit of omega-3 polyunsaturated
fatty acids (ω-3 PUFAs) on nonalcoholic fatty liver disease (NAFLD) have reported …

NAFLD is the leading cause of chronic liver disease in the Western world with an estimated
prevalence of 20–30%. Lifestyle interventions targeted at weight loss through dietary …