In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

The artificial engineering of an enzyme's structural conformation to enhance its activity is
highly desired and challenging. Anisotropic reticular chemistry, best illustrated in the case of …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Re-engineering enzymes with high activities in the given environments different from the
physiological one has been constantly pursued for application of enzymatic catalysis in …

Mitochondrial energetics and respiration have emerged as important factors in how cancer
cells respond to or evade apoptotic signals. The study of the functional connection between …

Cardiolipin is a unique phospholipid which is almost exclusively located in the inner
mitochondrial membrane where it is biosynthesized. Considerable progress has recently …

Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

In addition to the well-established role of the mitochondria in energy metabolism, regulation
of cell death has recently emerged as a second major function of these organelles. This, in …