Tissue microcirculation is essential for the maintenance of organ homeostasis. Following
acute infections, activation of coagulation and inflammation, which are critical …

Introduction COVID-19 is associated to an increased risk of thrombosis, as a result of a
complex process that involves the activation of vascular and circulating cells, the release of …

Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while
20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care …

Several predictive biomarkers for coronavirus disease (COVID-19)-associated mortality in
critically ill patients have been described. Although mitochondrial DNA (mtDNA) is elevated …

Certain stimuli, such as microorganisms, cause neutrophils to release neutrophil
extracellular traps (NETs), which are basically web-like structures composed of DNA with …

Septic patients were commonly affected by coagulation disorders; thus, they are at high risk
of thrombotic complications. In the last decades, novel knowledge has emerged about the …

Thrombotic complications pose serious health risks worldwide. A significant change in our
understanding of the pathophysiology of thrombosis has occurred since the discovery of …

Background Thrombo-inflammation and neutrophil extracellular traps (NETs) are
exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation …

Peripheral blood polymorphonuclear neutrophils (PMNs) forming extracellular traps (NETs),
as well as endothelial-and platelet-derived parameters, have been analyzed in patients with …

Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and
the alleviation and treatment of ARDS remains a major research focus. There are various …