Background Genetic alterations of somatic cells can drive non-malignant clone formation
and promote cancer initiation. However, the link between these processes remains unclear …

Cancer is a complex disease at many different levels. The molecular phenomenology of
cancer is also quite rich. The mutational and genomic origins of cancer and their …

Previous studies studying mis-splicing mutations were based on exome data and thus our
current knowledge is largely limited to exons and the canonical splice sites. To …

Follicular lymphoma (FL) is clinically heterogeneous, with select patients tolerating extended
watch-and-wait, whereas others require prompt treatment, suffer progression of disease …

Familial aggregation of Hodgkin lymphoma (HL) has been demonstrated in large population
studies, pointing to genetic predisposition to this hematological malignancy. To understand …

Angioimmunoblastic T‑cell lymphoma (AITL) is a uniquely aggressive mature T‑cell
neoplasm. In recent years, recurrent genetic mutations in ras homolog family member A …

The search for oncogenic mutations in haematological malignancies has largely focused on
coding sequence variants. These variants have been critical in understanding these …

Cancer-related mutations have been mainly identified in protein-coding regions. Recent
studies have demonstrated that mutations in non-coding regions of the genome could also …

Background Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with
one of the highest world incidences in the Eastern Cape region of South Africa. Several …

Human chromosomes are large spatially and hierarchically structured entities, the integrity
of which needs to be preserved throughout the lifespan of the cell and in conjunction with …