Computational psychiatry: from synapses to sentience

K Friston - Molecular psychiatry, 2023 - nature.com
This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …

The importance of sensory processing in mental health: a proposed addition to the research domain criteria (RDoC) and suggestions for RDoC 2.0

LA Harrison, A Kats, ME Williams… - Frontiers in …, 2019 - frontiersin.org
The time is ripe to integrate burgeoning evidence of the important role of sensory and motor
functioning in mental health within the National Institute of Mental Health's [NIMH] Research …

Pain, from perception to action: a computational perspective

ZS Chen, J Wang - Iscience, 2023 - cell.com
Pain is driven by sensation and emotion, and in turn, it motivates decisions and actions. To
fully appreciate the multidimensional nature of pain, we formulate the study of pain within a …

Computational and neural mechanisms of statistical pain learning

F Mancini, S Zhang, B Seymour - Nature Communications, 2022 - nature.com
Pain invariably changes over time. These fluctuations contain statistical regularities which, in
theory, could be learned by the brain to generate expectations and control responses. We …

CLAMS: A Cluster Ambiguity Measure for Estimating Perceptual Variability in Visual Clustering

H Jeon, GJ Quadri, H Lee, P Rosen… - … on Visualization and …, 2023 - ieeexplore.ieee.org
Visual clustering is a common perceptual task in scatterplots that supports diverse analytics
tasks (eg, cluster identification). However, even with the same scatterplot, the ways of …

Boundary effects of expectation in human pain perception

EJ Hird, C Charalambous, W El-Deredy, AKP Jones… - Scientific reports, 2019 - nature.com
Perception of sensory stimulation is influenced by numerous psychological variables. One
example is placebo analgesia, where expecting low pain causes a painful stimulus to feel …

A deeper look at pain variability and its relationship with the placebo response: results from a randomized, double-blind, placebo-controlled clinical trial of naproxen in …

R Treister, L Honigman, OD Lawal, RK Lanier, NP Katz - Pain, 2019 - journals.lww.com
Previous studies have shown a robust correlation between variability of clinical pain scores
and responsiveness to placebo (but not active drug) in pain studies, but explanations for …

A parahippocampal-sensory Bayesian vicious circle generates pain or tinnitus: a source-localized EEG study

D De Ridder, K Friston, W Sedley… - Brain …, 2023 - academic.oup.com
Pain and tinnitus share common pathophysiological mechanisms, clinical features, and
treatment approaches. A source-localized resting-state EEG study was conducted in 150 …

Perceptual variability: Implications for learning and generalization

J Zaman, A Chalkia, AK Zenses, AS Bilgin… - Psychonomic Bulletin & …, 2021 - Springer
The generalization of learned behavior has been extensively investigated, but accounting
for variance in generalized responding remains a challenge. Based on recent advances, we …

Does active inference provide a comprehensive theory of placebo analgesia?

C Milde, LS Brinskelle, JA Glombiewski - Biological Psychiatry: Cognitive …, 2023 - Elsevier
Placebo interventions generate mismatches between expected pain and sensory signals
from which pain states are inferred. Since we lack direct access to bodily states, we can only …