Coenzyme Q10 effects in neurodegenerative disease

M Spindler, MF Beal, C Henchcliffe - Neuropsychiatric disease and …, 2009 - Taylor & Francis
Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and
as a dietary supplement it has recently gained attention for its potential role in the treatment …

Antioxidants as treatment for neurodegenerative disorders

B Moosmann, C Behl - Expert opinion on investigational drugs, 2002 - Taylor & Francis
Oxidative stress is a ubiquitously observed hallmark of neurodegenerative disorders.
Neuronal cell dysfunction and cell death due to oxidative stress may causally contribute to …

Bioenergetic approaches for neuroprotection in Parkinson's disease

MF Beal - Annals of Neurology: Official Journal of the American …, 2003 - Wiley Online Library
There is considerable evidence suggesting that mitochondrial dysfunction and oxidative
damage may play a role in the pathogenesis of Parkinson's disease (PD). This possibility …

[HTML][HTML] Coenzyme Q10 effects in neurological diseases

H Rauchova - Physiological research, 2021 - ncbi.nlm.nih.gov
Summary Coenzyme Q 10 (CoQ 10), a lipophilic substituted benzoquinone, is present in
animal and plant cells. It is endogenously synthetized in every cell and involved in a variety …

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease

A Storch, WH Jost, P Vieregge, J Spiegel… - Archives of …, 2007 - jamanetwork.com
Background Major hallmarks in the pathophysiology of Parkinson disease are cellular
energy depletion and oxidative stress leading to cellular dysfunction and death. Coenzyme …

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

M Sanoobar, S Eghtesadi, A Azimi, M Khalili… - Nutritional …, 2015 - Taylor & Francis
Objectives Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of
central nervous system and recent studies show that inflammatory processes are highly …

Nitric oxide and neurological disorders

AJ Duncan, SJR Heales - Molecular aspects of medicine, 2005 - Elsevier
This article aims to give a broad overview of some of the potential targets for nitric oxide
(NO) in the brain. The relevance of NO in both physiological and pathological scenarios is …

Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease

M Sohmiya, M Tanaka, NW Tak, M Yanagisawa… - Journal of the …, 2004 - Elsevier
Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's
disease (PD). However, no elevation of plasma oxidative stress marker has been reported …

Coenzyme Q 10 as a possible treatment for neurodegenerative diseases

M Flint Beal - Free Radical Research, 2002 - Taylor & Francis
Coenzyme Q 10 (CoQ 10) is an essential cofactor of the electron transport gene as well as
an important antioxidant, which is particularly effective within mitochondria. A number of …

Nitric oxide and mitochondrial function in neurological diseases

M Ghasemi, Y Mayasi, A Hannoun, SM Eslami… - Neuroscience, 2018 - Elsevier
Mitochondria are key cellular organelles that play crucial roles in the energy production and
regulation of cellular metabolism. Accumulating evidence suggests that mitochondrial …