Gene evolution has long been thought to be primarily driven by duplication and
rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes …

Our recent ability to sequence entire genomes, along with all of their transcribed RNAs, has
led to the surprising finding that only∼ 1% of the human genome is used to encode proteins …

De novo gene birth is the process by which new genes evolve from DNA sequences that
were ancestrally non-genic. De novo genes represent a subset of novel genes, and may be …

The role of de novo evolved genes from non-coding sequences in regulating morphological
differentiation between species/subspecies remains largely unknown. Here, we show that a …

Deep transcriptome sequencing has revealed the existence of many transcripts that lack
long or conserved open reading frames (ORFs) and which have been termed long non …

During the course of evolution, genomes acquire novel genetic elements as sources of
functional and phenotypic diversity, including new genes that originated in recent evolution …

The study of de novo protein-coding genes is maturing from the ad hoc reporting of
individual cases to the systematic analysis of extensive genomic data from several species …

The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and
provides a hotspot for the origination of genetic novelties such as de novo genes …

Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

Genes are perpetually added to and deleted from genomes during evolution. Thus, it is
important to understand how new genes are formed and how they evolve to be critical …