Iron and leukemia: new insights for future treatments

F Wang, H Lv, B Zhao, L Zhou, S Wang, J Luo… - Journal of Experimental …, 2019 - Springer
Iron, an indispensable element for life, is involved in all kinds of important physiological
activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress …

Response and toxicity to cytarabine therapy in leukemia and lymphoma: from dose puzzle to pharmacogenomic biomarkers

R Di Francia, S Crisci, A De Monaco, C Cafiero, A Re… - Cancers, 2021 - mdpi.com
Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …

[HTML][HTML] A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake

LR Devireddy, C Gazin, X Zhu, MR Green - Cell, 2005 - cell.com
The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including
apoptosis due to interleukin-3 (IL-3) deprivation and iron transport. Here we report cloning of …

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …

DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia

S Weber, A Parmon, N Kurrle, F Schnütgen… - Frontiers in …, 2021 - frontiersin.org
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases leading to an insufficient formation of functional blood …

Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

H Sebai, MA Jabri, A Souli, K Rtibi, S Selmi… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance Matricaria recutita L.(Chamomile) has been widely used in
the Tunisian traditional medicine for the treatment of digestive system disorders. The present …

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

Y Eberhard, SP McDermott, X Wang… - Blood, The Journal …, 2009 - ashpublications.org
Off-patent drugs with previously unrecognized anticancer activity could be rapidly
repurposed for this new indication. To identify such compounds, we conducted 2 …

Protective effects of orange (Citrus sinensis L.) peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol in rat

S Selmi, K Rtibi, D Grami, H Sebai… - Lipids in health and …, 2017 - Springer
Background Massive alcohol drinking can lead to gastric ulcer. In the present study we
investigated the gastroprotective effect of Citrus sinensis peel aqueous extract (CSPE) and …

Addressing the problem of cationic lipid-mediated toxicity: the magnetoliposome model

SJH Soenen, AR Brisson, M De Cuyper - Biomaterials, 2009 - Elsevier
The high biocompatibility and versatile nature of liposomes made these particles keystone
components in many hot-topic research areas. For transfection and cell labelling purposes …

[PDF][PDF] INVITED REVIEW-Apoptosis, the role of oxidative stress and the example of solar UV radiation

C Pourzand, RM Tyrrell - Photochemistry and photobiology, 1999 - academia.edu
The solar UV that reaches the earth's surface is divided into two components, UVB (280-320
nm) and UVA (320-380 nm). The UVB component, which is directly absorbed by cellular …