Application of metabolomics in toxicity evaluation of traditional Chinese medicines

L Duan, L Guo, L Wang, Q Yin, CM Zhang, YG Zheng… - Chinese Medicine, 2018 - Springer
Traditional Chinese medicines (TCM) have a long history of use because of its potential
complementary therapy and fewer adverse effects. However, the toxicity and safety issues of …

Discovery and identification of quality markers of Chinese medicine based on pharmacokinetic analysis

J He, X Feng, K Wang, C Liu, F Qiu - Phytomedicine, 2018 - Elsevier
Abstract Background Quality control of Chinese medicine (CM) is an effective measure to
ensure the safety and efficacy of CM in clinical practice, which is also a key factor to restrict …

Discovery of potential Q-marker of traditional Chinese medicine based on plant metabolomics and network pharmacology: Periplocae Cortex as an example

Z Li, F Zhang, C Fan, M Ye, W Chen, Z Yao, X Yao… - Phytomedicine, 2021 - Elsevier
Background Quality control exerted great importance on the clinical application of drugs for
ensuring effectiveness and safety. Due to chemical complexity, diversity among different …

Analyzing the systems biology effects of COVID-19 mRNA vaccines to assess their safety and putative side effects

R Hajjo, DA Sabbah, A Tropsha - Pathogens, 2022 - mdpi.com
COVID-19 vaccines have been instrumental tools in reducing the impact of SARS-CoV-2
infections around the world by preventing 80% to 90% of hospitalizations and deaths from …

Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway

Y Cheng, G Wang, L Zhao, S Dai, J Han, X Hu… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is one of the most common cancers worldwide, and approximately
one-third of CRC patients present with metastatic disease. Periplocymarin (PPM), a cardiac …

Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway

JP Lin, MH Huang, ZT Sun, L Chen, YH Lei, YQ Huang… - Life Sciences, 2023 - Elsevier
Aims We aimed to evaluate the effect of periplocin on inhibiting hepatocellular carcinoma
(HCC) and further determine its mechanisms. Main methods Cytotoxic activity of periplocin …

Periplocin overcomes bortezomib resistance by suppressing the growth and down-regulation of cell adhesion molecules in multiple myeloma

A Aziz, H Wang, Y Wang, Z Li, C Yang, Z Ma, X Xiao… - Cancers, 2023 - mdpi.com
Simple Summary Multiple myeloma (MM) is a hematologic disorder that is incurable and
relapses due to its resistance capability towards bortezomib (BTZ). Our study aimed to …

[HTML][HTML] Differential Chemical Components Analysis of Periplocae Cortex, Lycii Cortex, and Acanthopanacis Cortex Based on Mass Spectrometry Data and …

X Wang, J Zhang, F He, W Jing, M Li, X Guo, X Cheng… - Molecules, 2024 - mdpi.com
Background: Periplocae Cortex (PC), Acanthopanacis Cortex (AC), and Lycii Cortex (LC), as
traditional Chinese medicines, are all dried root bark, presented in a roll, light and brittle …

[HTML][HTML] Periplocin mediates TRAIL-induced apoptosis and cell cycle arrest in human myxofibrosarcoma cells via the ERK/p38/JNK pathway

B Lohberger, E Bernhart, N Stuendl, D Glaenzer… - Phytomedicine, 2020 - Elsevier
Background Periploca sepium is traditionally used in Chinese medicine to treat particularly
rheumatic disorders and as a tonic. Periplocin was found as the most cytotoxic compound of …

Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis

B Lohberger, S Wagner, J Wohlmuther, H Kaltenegger… - Phytomedicine, 2018 - Elsevier
Background: During a screening of Chinese plants traditionally used for the treatment of
cancer and related diseases, extracts of the root bark of Periploca sepium Bunge showed …