The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded
as a functionally diverse mediator of homeostasis. During development and throughout …

Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-
associated macrophages (CAMs) are resident immune cells located along the brain …

Microglia play key roles in the post‐ischemic inflammatory response and damaged tissue
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …

Spinal cord injury (SCI) causes lifelong debilitating conditions. Previous works demonstrated
the essential role of the immune system in recovery after SCI. Here, we explored the …

A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain | Science
Translational Medicine news careers commentary Journals Science Science brought to you …

Major histocompatibility complex I (MHC-I) CNS cellular localization and function is still
being determined after previously being thought to be absent from the brain. MHC-I …

Background Retinal degeneration is a disease affecting the eye, which is an immune-
privileged site because of its anatomical and physiological properties. Alterations in retinal …

The primary mechanism of secondary injury after cerebral ischemia may be the brain
inflammation that emerges after an ischemic stroke, which promotes neuronal death and …

Reactive microglia are observed with aging and in Lewy body disorders, including within the
olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia …

The importance of the brain-heart interaction has been increasingly recognized as a critical
physiological axis that is altered in disease. In this review, we explore the intricate …