Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic
responses to infection, thereby compromising host homeostasis. Activation of the …

Crohn's disease is an inflammatory disease of the gastrointestinal tract characterized by an
aberrant response to microbial and environmental triggers. This includes an altered …

Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory
diseases, and endogenous GCs play a key role in immune regulation. Toll-like receptors …

Gut microbiota imbalances play an important role in inflammatory bowel disease (IBD), but
no single pathogenic microorganism critical to IBD that is specific to the IBD terminal ileum …

Glucocorticoids are effective drugs for treating immune-related diseases, but prolonged
therapy is associated with an increased risk of various infectious diseases, including …

The effect of stress on male fertility is a widespread public health issue, but less is known
about the related signaling pathway. To investigate this, we established a hypercortisolism …

Activation of toll-like receptors (TLRs) plays a pivotal role in the host defense against
bacteria and results in the activation of NF-κB-mediated transcription of proinflammatory …

Crohn's disease (CD) is a severe chronic immune-mediated granulomatous inflammatory
disease of the gastrointestinal tract. The mechanisms of CD pathogenesis remain obscure …

While cytostatic chemotherapy targeting DNA is known to induce genotoxicity, leading to cell
cycle arrest and cytokine secretion, the impact of these drugs on fibroblast–epithelial cancer …