The versatility in the applications of dithiocarbamates

TO Ajiboye, TT Ajiboye, R Marzouki… - International Journal of …, 2022 - mdpi.com
Dithiocarbamate ligands have the ability to form stable complexes with transition metals, and
this chelating ability has been utilized in numerous applications. The complexes have also …

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

A Negre‐Salvayre, C Coatrieux… - British journal of …, 2008 - Wiley Online Library
Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar
glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and Advanced …

[HTML][HTML] NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

JA Roman-Blas, SA Jimenez - Osteoarthritis and cartilage, 2006 - Elsevier
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

E Jimi, K Aoki, H Saito, F D'Acquisto, MJ May… - Nature medicine, 2004 - nature.com
Bone destruction is a pathological hallmark of several chronic inflammatory diseases,
including rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of this sort …

The functional role of poly (ADP-ribose) polymerase 1 as novel coactivator of NF-κB in inflammatory disorders

PO Hassa, MO Hottiger - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
Mammalian poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear chromatin-
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …

Spinal NF‐kB activation induces COX‐2 upregulation and contributes to inflammatory pain hypersensitivity

KM Lee, BS Kang, HL Lee, SJ Son… - European Journal of …, 2004 - Wiley Online Library
Abstract Cyclooxygenase‐2 (COX‐2) is a major contributor to the elevation of spinal
prostaglandin E2, which augments the processing of nociceptive stimuli following peripheral …

[HTML][HTML] Histamine induces bovine rumen epithelial cell inflammatory response via NF-κB pathway

X Sun, X Yuan, L Chen, T Wang, Z Wang… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Subacute ruminal acidosis (SARA) is a common disease in high-
producing lactating cows. Rumenitis is the initial insult of SARA and is associated with the …

Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma

ND Walker, M Elias, K Guiro, R Bhatia, SJ Greco… - Cell death & …, 2019 - nature.com
Breast cancer (BC) cells (BCCs) can retain cellular quiescence for decades, a phenomenon
referred to as dormancy. BCCs show preference for the bone marrow (BM) where they can …

Antioxidant therapy as a potential approach to severe influenza-associated complications

N Uchide, H Toyoda - Molecules, 2011 - mdpi.com
With the appearance of the novel influenza A (H1N1) virus 2009 strain we have experienced
a new influenza pandemic and many patients have died from severe complications …