Spatiotemporal regulation of signaling: focus on T cell activation and the immunological synapse

E Garcia, S Ismail - International journal of molecular sciences, 2020 - mdpi.com
In a signaling network, not only the functions of molecules are important but when (temporal)
and where (spatial) those functions are exerted and orchestrated is what defines the …

Mosaic physiology from developmental noise: within-organism physiological diversity as an alternative to phenotypic plasticity and phenotypic flexibility

HA Woods - Journal of Experimental Biology, 2014 - journals.biologists.com
A key problem in organismal biology is to explain the origins of functional diversity. In the
context of organismal biology, functional diversity describes the set of phenotypes, across …

From fluctuations to phenotypes: the physiology of noise

MS Samoilov, G Price, AP Arkin - Science's STKE, 2006 - science.org
There are fundamental physical reasons why biochemical processes might be subject to
noise and stochastic fluctuations. Indeed, it has long been understood that random …

Optimal enumeration of state space of finitely buffered stochastic molecular networks and exact computation of steady state landscape probability

Y Cao, J Liang - BMC Systems Biology, 2008 - Springer
Background Stochasticity plays important roles in many molecular networks when molecular
concentrations are in the range of 0.1 μ M to 10 n M (about 100 to 10 copies in a cell). The …

Intrinsic fluctuations, robustness, and tunability in signaling cycles

J Levine, HY Kueh, L Mirny - Biophysical journal, 2007 - cell.com
Covalent modification cycles (eg, phosphorylation-dephosphorylation) underlie most cellular
signaling and control processes. Low molecular copy number, arising from compartmental …

Effect of calcium channel noise in astrocytes on neuronal transmission

J Tang, TB Liu, J Ma, JM Luo, XQ Yang - Communications in Nonlinear …, 2016 - Elsevier
In this study, a Langevin model is constructed by modifying a neuron–astrocyte coupled
model that comprises a pyramidal neuron, an interneuron, and an astrocyte. This Langevin …

Coherence resonance induced by cross-correlated sine-Wiener noises in the FitzHugh–Nagumo neurons

Y Yao, M Yi, D Hou - International Journal of Modern Physics B, 2017 - World Scientific
We study coherence resonance (CR) in the FitzHugh–Nagumo (FHN) neurons under cross-
correlated sine-Wiener (CCSW) noises. It is numerically demonstrated that the reciprocal …

Accuracy of positional information provided by multiple morphogen gradients with correlated noise

Y Morishita, Y Iwasa - Physical Review E—Statistical, Nonlinear, and Soft …, 2009 - APS
Normal development of multicellular organisms requires cells to respond properly according
to their positions. Positional information is often provided to cells as concentrations of …

BioRxToolbox: a computational framework to streamline genetic circuit design in molecular data communications

MG Durmaz, N Tulluk, RD Aksoy, HB Yilmaz… - Synthetic …, 2024 - academic.oup.com
Developments in bioengineering and nanotechnology have ignited the research on
biological and molecular communication systems. Despite potential benefits, engineering …

Multiplicative-noise-induced coherence resonance via two different mechanisms in bistable neural models

J Tang, Y Jia, M Yi, J Ma, J Li - Physical Review E—Statistical, Nonlinear, and …, 2008 - APS
The bistable FitzHugh-Nagumo (FHN) neural model driven by two multiplicative noises and
one additive noise is investigated. Two different potential mechanisms for enhancing …