With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to
explore non-conventional therapeutic measures to alleviate the burden of CVD on global …

Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Functional mitochondria are critically important for the maintenance of cellular integrity and
survival. Mitochondrial dysfunction is a major contributor to neurodegenerative diseases …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in
mitochondrial quality control pathways remains unexplored. Here we describe a mechanism …

PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been
identified as the causal genes responsible for hereditary recessive early-onset …

PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of
damaged mitochondria. However, it has been unclear how PINK1 activates and recruits …

Phosphorylation is often used to promote protein ubiquitylation, yet we rarely understand
quantitatively how ligase activation and ubiquitin (UB) chain assembly are integrated with …

Mitochondria-specific autophagy (mitophagy) is a fundamental process critical for
maintaining mitochondrial fitness in a myriad of cell types. Particularly, mitophagy …