Glycosylation is catalyzed by various glycosyltransferase enzymes which are mostly located
in the Golgi apparatus in cells. These enzymes glycosylate various complex carbohydrates …

Fucosylated carbohydrate structures are involved in a variety of biological and pathological
processes in eukaryotic organisms including tissue development, angiogenesis, fertilization …

Summary Programmed cell death 1 (PD-1) is highly expressed on exhausted T cells and
inhibits T cell activation. Antibodies that block the interaction between PD-1 and its ligand …

Fucosylation is one of the most common modifications involving oligosaccharides on
glycoproteins or glycolipids. Fucosylation comprises the attachment of a fucose residue to N …

It is essential to utilize deep-learning algorithms based on big data for the implementation of
the new generation of artificial intelligence. Effective utilization of deep learning relies …

The core fucosylation (α1, 6-fucosylation) of glycoproteins is widely distributed in
mammalian tissues, and is altered under pathological conditions. To investigate …

Chronic infection with hepatitis B virus (HBV) is associated with the majority of
hepatocellular carcinoma (HCC). The diagnosis of HCC is usually made in the late stages of …

α1, 6-Fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue to N-linked
oligosaccharides on glycoproteins via an α1, 6-linkage to form core fucosylation in …

Background One of the new roles for enzymes in personalized medicine builds on a rational
approach to cancer biomarker discovery using enzyme-associated aberrant glycosylation. A …

Protein glycosylation is a posttranslational modification that affects more than half of all
known proteins. Glycans covalently bound to biomolecules modulate their functions by both …