The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

A bewildering number of host cell proteins associated with Nef can be found in the literature
and in the public protein interaction databases. However, only in a few of these cases …

Severe pulmonary hypertension (PH) associated with vascular remodeling is a long-term
complication of HIV infection (HIV-PH) affecting 1/200 infected individuals vs. 1/200,000 …

HIV-1 Nef supports high titer viral replication in vivo and is essential for AIDS progression.
Nef function depends on interactions with multiple host cell effectors, including Hck and …

Objective—HIV-infected patients are at an increased risk of developing atherosclerosis, in
part because of downmodulation and functional impairment of ATP-binding cassette A1 …

Many proteins are posttranslationally modified by acylation targeting them to lipid
membranes. While methods such as X-ray crystallography and nuclear magnetic resonance …

Highlights•Insight into new strategies in HIV therapy.•Targeting protein–protein interactions
in HIV.•Targeting cellular cofactors in HIV.Two novel approaches for the development of new …

HIV-1 Nef is a flexible, multifunctional protein with several cellular targets that is required for
pathogenicity of the virus. This protein maintains a high degree of genetic variation among …

Background HIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus.
As Nef has no known enzymatic activity, it necessarily functions through protein-protein …

Abstract The Human Immunodeficiency Virus (HIV) is the cause of the AIDS disease. To
date, more than 30 million people worldwide are infected with HIV-1, which causes two …