Glioblastoma: current status, emerging targets, and recent advances
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …
population of genetically unstable and highly infiltrative cells that are resistant to …
[HTML][HTML] Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins
Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …
Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy
P Xu, R Ge - European journal of medicinal chemistry, 2022 - Elsevier
Methyltransferase complex, such as METTL3/METTL14/WTP, catalyze N 6-methyladenosine
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …
(m 6 A), which is the most abundant mRNA modification in mammals. Besides acting as am …
Deciphering the lexicon of protein targets: a review on multifaceted drug discovery in the era of artificial intelligence
Understanding protein sequence and structure is essential for understanding protein–
protein interactions (PPIs), which are essential for many biological processes and diseases …
protein interactions (PPIs), which are essential for many biological processes and diseases …
Androgen receptor, although not a specific marker for, is a novel target to suppress glioma stem cells as a therapeutic strategy for glioblastoma
Targeting androgen receptor (AR) has been shown to be promising in treating glioblastoma
(GBM) in cell culture and flank implant models but the mechanisms remain unclear. AR …
(GBM) in cell culture and flank implant models but the mechanisms remain unclear. AR …
Targeting heat shock proteins in Malignant brain tumors: from basic research to clinical trials
Simple Summary Heat shock proteins (HSPs) play an important role in cellular metabolism
and therefore are highly expressed in malignant brain tumors. In the current review, the …
and therefore are highly expressed in malignant brain tumors. In the current review, the …
Targeting androgen receptor in glioblastoma
X Gan, X Wang, Y Liu - Critical Reviews in Oncology/Hematology, 2023 - Elsevier
Glioblastomas are primary brain tumors that originate from glial stem cells or progenitor
cells. There is a large difference in the incidence of glioblastoma between males and …
cells. There is a large difference in the incidence of glioblastoma between males and …
Astragalus membranaceus Extract Induces Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Heat Shock Protein 27 and Androgen Receptor in …
Although Astragalus membranaceus is known to have anti-inflammatory, anti-obesity, and
anti-oxidant properties, the underlying apoptotic mechanism of Astragalus membranaceus …
anti-oxidant properties, the underlying apoptotic mechanism of Astragalus membranaceus …
Lead Optimization of Androgen Receptor-HSP27 Disrupting Agents in Glioblastoma
Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis under
the current standard treatment. It is critical to develop new approaches to selectively battle …
the current standard treatment. It is critical to develop new approaches to selectively battle …
Pharmacokinetic and brain distribution study of an anti‐glioblastoma agent in mice by HPLC–MS/MS
Previously compound I showed great anti‐glioblastoma activity without toxicity in a mouse
xenograft study. In this study, a sensitive and rapid high‐performance liquid chromatography …
xenograft study. In this study, a sensitive and rapid high‐performance liquid chromatography …